Our research has numerous characteristics and limitations

Our research has numerous characteristics and limitations

The target build faster the possibility of keep in mind and you may solutions biases, and also the higher rate of storage smaller bias on account of a good losings to follow-right up. Diet is analyzed multiple times while in the follow-upwards, hence got into consideration changes in dinner habits and you will shorter dimensions error; but not, some error try inescapable. Even though strokes were notice-said, research medical professionals, with no knowledge of the latest thinking-advertised exposure grounds reputation regarding professionals, assessed participants’ scientific details to verify the fresh stroke diagnosis and identify the fresh coronary attack kind of. Although not, while the twenty four% of women with heart attack on the NHS I and thirty-two% from the NHS II did not bring permission to examine its medical ideas, we had been struggling to categorize the strokes given that ischemic or hemorrhagic; hence, the fresh new quantities of coronary arrest types were less. However, the enormous amount of people plus the long duration of follow-upwards offered enough capacity to detect clinically relevant variations in risks out of overall stroke and you may coronary arrest sizes. At exactly the same time, the new up-to-date meta-analyses given help in regards to our findings on the fat reduction consumption away from magnesium, potassium, and you can calcium supplements and you may threat of full coronary arrest. A primary limitation of your current research is the shortcoming so you can independent new independent ramifications of the 3 nutritional elements which have far certainty by the higher correlations between them. In addition to, once the analysis populace mainly contained Caucasian ladies ( 12), the outcomes of current investigation may possibly not be generalizable to help you guys or ethnically diverse communities.

To close out, comes from this type of 2 high potential education bring good facts in order to support an enthusiastic inverse connection between shared consumption of magnesium, potassium, and you will calcium supplements off diet and stroke exposure. The brand new independent role of each nutrient from the decrease in coronary arrest exposure is difficult to define. As well, the effect of these minerals with the chance of coronary arrest independent of dinner source is hard in order to explain. This research supports guidance of your own Dieting Methods to Avoid Blood pressure, Max Macronutrient Consumption Demo to end Heart disease, and you can Mediterranean diet, hence render high weight-loss intake of those nutrients.

The new authors’ requirements had been below-SNA: did statistical analyses and you will penned the manuscript; DS, WCW, and KMR: considering critical views of one’s manuscript; and all writers: understand and you may recognized the past manuscript. None of the experts claimed a dispute interesting connected with the research.


Backed by the brand new NIH (features UM1CA176726, UM1CA186107, D43TW009106, HL34594, CA87969, and you will HL088521) therefore the Bernard Lown Cardiovascular illnesses Program (to SNA).


Information was obtained on potential confounding factors, including medical history, other aspects of dietary intake, and lifestyle behaviors that could be associated with intake of these minerals and risk of stroke. These variables were updated biennially and included cigarette smoking (never, past, or current), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks per week), menopausal status (premenopausal or postmenopausal), postmenopausal hormone therapy use (never, past, or current), parental history of early myocardial infarction (before age 60 y), multivitamin use (yes or no), thiazide use (yes or no), aspirin use at least 2 times/wk (yes or no), and history of hypertension, diabetes, or hypercholesterolemia (yes or no). Height and weight were self-reported at baseline, and weight was updated from follow-up questionnaire responses. BMI (in kg/m 2 ) was calculated as weight divided by height squared. BMI was divided into 3 categories (i.e., <25, 25 to <30, and ?30). Quintiles were calculated for total energy intake (kcal), and we used alcohol consumption categories of 0, 0 to <5, 5 to <10, 10 to <15, and ?15 g/d.

Age-standardized functions away from 86,149 ladies in this new NHS We within the 1994 and 94,715 women in new NHS II in the 1995 of the quintiles from magnesium, potassium, and you can calcium supplements consumption step one

Pooled RRs (95% CIs) regarding full, ischemic, and hemorrhagic strokes because of the quintiles regarding full and dieting potassium consumption in the 86,149 ladies in the fresh NHS We and you will 94,715 feamales in the newest NHS II step one

From the seemingly large degree of relationship between these minerals, we plus tested a mixed magnesium, potassium, and you can calcium supplements diet plan score ( Table 5). To possess evaluation of females in the higher having reduced quintiles away from shared magnesium, potassium, and you can calcium diet plan score, https://datingranking.net/gay-dating/ new pooled multivariate RR to have complete stroke try 0.81 (95% CI: 0.72, 0.91; P-development = 0.003). Conclusions were comparable to possess ischemic however hemorrhagic coronary attack.


The new relation anywhere between consumption from magnesium, potassium, and calcium and you will likelihood of stroke revealed in the current research is much like the new relation anywhere between intake of those nutrients and you may likelihood of IHD. For the potential degree, weight-loss consumption out of magnesium and potassium was inversely of the risk off IHD ( 46, 47), but there can be zero relatives with calcium supplements consumption and you will chance of IHD in females ( 48). Including, intakes out-of magnesium and you will calcium supplements not potassium was indeed on the all the way down likelihood of CVD death in some ( twenty four, 46, 49) however all the ( 50) studies.

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