The analysis has numerous strengths and limitations

The analysis has numerous strengths and limitations

The goal framework faster the potential for remember and you can options biases, and higher rate off maintenance smaller bias because of a good loss to adhere to-right up. Diet is actually assessed many times during the go after-upwards, and this grabbed into account alterations in restaurants practices and you will shorter dimensions error; yet not, specific error are inevitable. Even when shots was indeed notice-stated, study physicians, lacking the knowledge of brand new care about-stated exposure foundation position off people, analyzed participants’ scientific info to confirm the latest coronary attack medical diagnosis and you may identify the stroke form of. But not, since the 24% of women that have coronary attack about NHS I and you can 32% on NHS II didn’t offer permission to examine their scientific suggestions, we had been incapable of categorize all the strokes while the ischemic or hemorrhagic; for this reason, the fresh new variety of coronary arrest types have been faster. Still, the enormous quantity of participants as well as the much time time of go after-upwards given adequate power to select medically relevant variations in dangers away from total coronary arrest and you will stroke sizes. At exactly the same time, the up-to-date meta-analyses given help for our results towards weightloss consumption out-of magnesium, potassium, and calcium and risk of overall heart attack. A primary restriction of your own most recent analysis was the inability so you can separate the latest separate ramifications of the three minerals which have much certainty of the large correlations between the two. Also, because analysis society mainly contained Caucasian lady ( 12), the outcome of your most recent research is almost certainly not generalizable so you’re able to men otherwise ethnically diverse communities.

To summarize, results from this type of 2 high possible knowledge provide strong facts to assistance a keen inverse association ranging from shared intakes from magnesium, potassium, and calcium off dieting and coronary arrest risk. The latest separate character of each mineral on reduction of heart attack exposure is hard so you’re able to explain. Additionally, the result of those nutritional elements to the threat of coronary arrest independent away from eating supply is hard so you can establish. This research aids counsel of one’s Weight loss Methods to End Blood pressure level, Max Macronutrient Intake Trial to stop Heart problems, and you can Mediterranean diet, and that provide high dieting intake ones vitamins.

The fresh new authors’ duties had been as follows-SNA: performed analytical analyses and authored the manuscript; DS, WCW, and you may KMR: provided important opinions of one’s manuscript; and all sorts of experts: understand and you will accepted the last manuscript. Nothing of the writers claimed a dispute interesting linked to the research.

FOOTNOTES

Supported by the new NIH (features UM1CA176726, UM1CA186107, D43TW009106, HL34594, CA87969, and HL088521) additionally the Bernard Lown Heart disease System (so you’re able to SNA).

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Information was obtained on Heterosexual dating dating app potential confounding factors, including medical history, other aspects of dietary intake, and lifestyle behaviors that could be associated with intake of these minerals and risk of stroke. These variables were updated biennially and included cigarette smoking (never, past, or current), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks per week), menopausal status (premenopausal or postmenopausal), postmenopausal hormone therapy use (never, past, or current), parental history of early myocardial infarction (before age 60 y), multivitamin use (yes or no), thiazide use (yes or no), aspirin use at least 2 times/wk (yes or no), and history of hypertension, diabetes, or hypercholesterolemia (yes or no). Height and weight were self-reported at baseline, and weight was updated from follow-up questionnaire responses. BMI (in kg/m 2 ) was calculated as weight divided by height squared. BMI was divided into 3 categories (i.e., <25, 25 to <30, and ?30). Quintiles were calculated for total energy intake (kcal), and we used alcohol consumption categories of 0, 0 to <5, 5 to <10, 10 to <15, and ?15 g/d.

Age-standard attributes off 86,149 feamales in the newest NHS I inside the 1994 and you may 94,715 feamales in brand new NHS II inside the 1995 from the quintiles out-of magnesium, potassium, and calcium supplements intakes step one

Pooled RRs (95% CIs) regarding complete, ischemic, and you may hemorrhagic strokes because of the quintiles from total and you may losing weight potassium consumption into the 86,149 ladies in the NHS We and 94,715 ladies in the fresh new NHS II step 1

By apparently higher amount of correlation ranging from these nutrients, we along with looked at a combined magnesium, potassium, and you can calcium supplements eating plan score ( Desk 5). For research of women regarding higher which have low quintiles regarding combined magnesium, potassium, and you may calcium eating plan get, the newest pooled multivariate RR to have full coronary arrest is actually 0.81 (95% CI: 0.72, 0.91; P-pattern = 0.003). Findings was equivalent getting ischemic however hemorrhagic stroke.

Discussion

Brand new family relations between consumption out-of magnesium, potassium, and calcium supplements and you may chance of stroke shown in the present study is much like the newest family anywhere between intake of them nutrients and likelihood of IHD. Into the potential training, fat reduction intake out of magnesium and you can potassium was inversely associated with the chance from IHD ( 46, 47), but you will find no relation that have calcium supplements intake and you will danger of IHD in females ( 48). Plus, intakes from magnesium and calcium not potassium was basically from the straight down threat of CVD mortality in certain ( twenty-four, 46, 49) but not the ( 50) knowledge.

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